BIOLOGIYA MORYA, 2017, Vol. 43, No. 4, pp. 263-270

Hypoxia-inducible factor 1α in the central nervous system of the scallop Mizuhopecten yessoensis (Jay, 1857) (Bivalvia: Pectinidae) during anoxia and elevated temperature

© 2017 E. P. Kotsyuba

A.V. Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041

E-mail:

An immunocytochemical method was used to study the distribution of hypoxia-inducible factor 1α (HIF-1α) in the central nervous system (CNS) of the scallop Mizuhopecten yessoensis (Jay, 1857) at anoxia and elevated temperature. HIF-1α was not detected in the CNS of control mollusks. After 2 h anoxia, HIF-1α was detected in neurons of the cerebral and visceral ganglia. It was found that a change in HIF-1α-immunoreactivity at anoxia had its own dynamics in each of the ganglia; these dynamics depended on the duration of anoxia and temperature. The presented data indicate the involvement of the transcription factor HIF-1α in providing the compensatory processes that contribute to activation of the neuroprotective mechanisms in the nervous ganglia that control vital functions in M. yessoensis at short-term hypoxia.

Key words: hypoxia-inducible factor 1α (HIF-1α), anoxia, central nervous system, bivalve mollusks.