BIOLOGIYA MORYA, 2015, Vol. 41, No. 5, pp. 366-373

Correction of toxic effect of cyclophosphamide on hemopoiesis in animals with lung Lewis carcinoma using low molecular sodium alginate

© 2015 O. Yu. Rybalkina^1,2, N. N. Ermakova¹, T. G. Razina¹, E. P. Zueva^1,2, E. G. Skurikhin¹, M. Yu. Khotimchenko³, R. Yu. Khotimchenko^3,4

¹E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk 634028;
¹National Research Tomsk State University, Tomsk 634050;
³School of Biomedicine, Far Eastern Federal University, Vladivostok 690091;
⁴A.V. Zhirmunsky Institute of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041

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This study examines the effect of low molecular sodium alginate, when injected alone and in combination with cyclophosphamide, on the peripheral blood and bone marrow in mice with lung Lewis carcinoma. Sodium alginate with a molecular weight of 1-10 and 20-30 kDa prevented the development of leukopenia and hampered the devastation of the bone marrow in animals with tumor. This is mediated by stimulating the regeneration of the granulocytic hemopoietic stem damaged by cytostatic therapy via the enhancement of the clonal activity of granulocytopoiesis precursors.

Key words: sodium alginate, hemopoiesis, lung Lewis carcinoma, chemotherapy.